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KMID : 0369820150450030301
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Jorunal of Korean Pharmaceutical Sciences
2015 Volume.45 No. 3 p.301 ~ p.309
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Preparation and evaluation of carbamazepine loaded fibrous electrospun mats of starch
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Meer Tarique Ali
Baig Mirza Shehzad
Amin Purnima D.
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Abstract
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The preset work deals with preparation of fibrous electrospun mats of starch (FEMOS) carrier, from naive starch, through a process of electrospinning. The developed FEMOS was explored for the solubility enhancement of poorly water soluble drug carbamazepine. Solid state characterization was performed with respect to Fourier transform infra-red spectroscopy, X-ray diffraction, scanning electron microscopy, contact angle determination, dissolution kinetics, and differential scanning calorimetry. Rapid release profiles were observed when the carbamazepine was loaded on FEMOS. This effect may be due to high surface area, improved wettability and reduced crystallinity of the loaded drug on FEMOS. The developed formulation was found to have a similar in vivo performance as compared to marketed formulation Tegretol®.
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KEYWORD
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Electrospinning, Carbamazepine, Dissolution, Solubility enhancement, Characterization
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